Renal Arginine Metabolism

Review: Arginine Metabolism Revisited

Mammalian arginine metabolism is complex due to the expression of multiple enzymes that utilize arginine as substrate and to interactions or competition between specific enzymes involved in arginine metabolism. Moreover, cells may contain multiple intracellular arginine pools that are not equally accessible to all arginine metabolic enzymes, thus presenting additional challenges to more fully u...

Bacterial metabolism of arginine.

Arginine metabolism and wound healing

The dibasic amino acid arginine is of fundamental importance in wound healing as it’s metabolites nitric oxide (NO), proline, and polyamines affect all phases of the wound healing process. In the wound milieu, the concentration of arginine may decrease to undetectable levels and in this context arginine shifts from being a non-essential to a semi-essential amino acid6 as these low concentration...

Arginine Metabolism: Enzymology, Nutrition, and Clinical Significance Enzymes of Arginine Metabolism

In mammals, L-arginine is classified as a semiessential or conditionally essential amino acid, depending on the developmental stage and health status of the individual. It can be derived from proline or glutamate, with the ultimate synthetic step catalyzed by argininosuccinate lyase. L-arginine is catabolized by arginases, nitric oxide synthases, arginine:glycine amidinotransferase, and possibl...

Arginine, citrulline, and nitric oxide metabolism in end-stage renal disease patients.

The kidneys are thought to be a major site of net de novo arginine synthesis, but the quantitative status of arginine metabolism and its substrate precursor relationship to nitric oxide (NO) synthesis in end stage renal disease (ESRD) patients have not been characterized. We have investigated kinetic aspects of whole body arginine metabolism in six patients with ESRD. They received two pre- and...